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After hours of delay, the Senate overwhelmingly voted for the $1.2 trillion bill to fund more than half of the government, sending the measure to President Biden’s desk.

Republicans, many of whom have said they support access to the treatment, have argued that it should be left to states to ensure its legality after an Alabama court ruled that frozen embryos were children.

The minority leader’s handling of the border and foreign aid legislation drew scorching criticism from far-right Republicans, though he scored a legislative win on an issue he regards as existential and part of his legacy.

The defeat of the immigration-Ukraine-Israel package marks the end of the party of Eisenhower, Reagan and McCain.

President Biden accused the House GOP of thwarting legislation tightening immigration rules and providing aid to Ukraine and Israel out of fear of their 2024 front-runner, Donald Trump.

The G.O.P. abandoned a bipartisan border security bill that also aided Ukraine after Democrats called their bluff on immigration, agreeing to tough measures Republicans demanded.

Republicans have scuttled efforts to rewrite immigration laws repeatedly over the past two decades, despite powerful bipartisan coalitions behind the efforts.

The former president’s opposition has all but killed the prospects for a bipartisan border deal, reflecting how his influence in Congress has grown as he gains ground in the Republican primary.

The minority leader privately told Republicans that the former president had put his party “in a quandary,” casting further doubt on the deal’s chances and the fate of Ukraine aid that the G.O.P. has tied to it.