How to increase serotonin in the human brain without drugs


1. Li D, He L. Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry 2006;12:47-54. [PubMed]

2. Neumeister A, Young T, Stastny J. Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter. Psychopharmacology (Berl) 2004;174:512-24. [PubMed]

3. Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003;8:646-53. [PubMed]

4. Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry 2003;8:574-91. [PubMed]

5. Gutknecht L, Jacob C, Strobel A, et al. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Int J Neuropsychopharmacol 2007;10:309-20. [PubMed]

6. Schoevers RA, Smit F, Deeg DJH, et al. Prevention of late-life depression in primary care: do we know where to begin? Am J Psychiatry 2006;163:1611-21. [PubMed]

7. van 't Veer-Tazelaar N, van Marwijk H, van Oppen P, et al. Prevention of anxiety and depression in the age group of 75 years and over: a randomized controlled trial testing the feasibility and effectiveness of a generic stepped care programme among elderly community residents at high risk of developing anxiety and depression versus usual care. BMC Public Health 2006;6:186. [PMC free article] [PubMed]

8. Barrett PM, Farrell LJ, Ollendick TH, et al. Long-term outcomes of an Australian universal prevention trial of anxiety and depression symptoms in children and youth: an evaluation of the friends program. J Clin Child Adolesc Psychol 2006;35:403-11. [PubMed]

9. Schotte CKW, Van Den Bossche B, De Doncker D, et al. A biopsychosocial model as a guide for psychoeducation and treatment of depression. Depress Anxiety 2006;23:312-24. [PubMed]

10. Whyte EM, Rovner B. Depression in late-life: shifting the paradigm from treatment to prevention. Int J Geriatr Psychiatry 2006;21:746-51. [PubMed]

11. Jorm AF, Griffiths KM. Population promotion of informal self-help strategies for early intervention against depression and anxiety. Psychol Med 2006;36:3-6. [PubMed]

12. Delamothe T. Happiness. BMJ 2005;331:1489-90. [PMC free article] [PubMed]

13. Wellbeing: an idea whose time has come. Lancet 2005;366:1412. [PubMed]

14. A sensible 10-year plan for mental health. Lancet 2006;367:86. [PubMed]

15. Miller TQ, Smith TW, Turner CW, et al. A meta-analytic review of research on hostility and physical health. Psychol Bull 1996;119:322-48. [PubMed]

16. Boyle SH, Williams RB, Mark DB, et al. Hostility as a predictor of survival in patients with coronary artery disease. Psychosom Med 2004;66:629-32. [PubMed]

17. Brummett BH, Barefoot JC, Siegler IC, et al. Characteristics of socially isolated patients with coronary artery disease who are at elevated risk for mortality. Psychosom Med 2001;63:267-72. [PubMed]

18. Brummett BH, Mark DB, Siegler IC, et al. Perceived social support as a predictor of mortality in coronary patients: effects of smoking, sedentary behavior, and depressive symptoms. Psychosom Med 2005;67:40-5. [PubMed]

19. Weiss A, Costa PT Jr. Domain and facet personality predictors of all-cause mortality among medicare patients aged 65 to 100. Psychosom Med 2005;67:724-33. [PubMed]

20. World Health Organization. Constitution of the World Health Organization. In: Basic documents, forty-fifth edition, supplement. 2006. Available: www.who.int/governance/eb/who_constitution_en.pdf (accessed 2007 Oct 3).

21. Danner DD, Snowdon DA, Friesen WV. Positive emotions in early life and longevity: findings from the Nun Study. J Pers Soc Psychol 2001;80:804-13. [PubMed]

22. Koivumaa-Honkanen H, Koskenvuo M, Honkanen RJ, et al. Life dissatisfaction and subsequent work disability in an 11-year follow-up. Psychol Med 2004;34:221-8. [PubMed]

23. Koivumaa-Honkanen H, Kaprio J, Honkanen R, et al. Life satisfaction and depression in a 15-year follow-up of healthy adults. Soc Psychiatry Psychiatr Epidemiol 2004;39:994-9. [PubMed]

24. Koivumaa-Honkanen H, Honkanen R, Koskenvuo M, et al. Self-reported happiness in life and suicide in ensuing 20 years. Soc Psychiatry Psychiatr Epidemiol 2003;38:244-8. [PubMed]

25. Koivumaa-Honkanen H, Honkanen R, Viinamäki H, et al. Self-reported life satisfaction and 20-year mortality in healthy Finnish adults. Am J Epidemiol 2000;152:983-91. [PubMed]

26. Lyubomirsky S, King L, Diener E. The benefits of frequent positive affect: does happiness lead to success? Psychol Bull 2005;131:803-55. [PubMed]

27. Southwick SM, Vythilingam M, Charney DS. The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annu Rev Clin Psychol 2005;1:255-91. [PubMed]

28. Caspi A, Roberts BW, Shiner RL. Personality development: stability and change. Annu Rev Psychol 2005;56:453-84. [PubMed]

29. Lee Duckworth A, Steen TA, Seligman MEP. Positive psychology in clinical practice. Annu Rev Clin Psychol 2005;1:629-51. [PubMed]

30. Peirson AR, Heuchert JW. Correlations for serotonin levels and measures of mood in a nonclinical sample. Psychol Rep 2000;87:707-16. [PubMed]

31. Williams E, Stewart-Knox B, Helander A, et al. Associations between whole-blood serotonin and subjective mood in healthy male volunteers. Biol Psychol 2006;71:171-4. [PubMed]

32. Zald DH, Depue RA. Serotonergic functioning correlates with positive and negative affect in psychiatrically healthy males. Pers Individ Dif 2001;30:71-86.

33. Flory JD, Manuck SB, Matthews KA, et al. Serotonergic function in the central nervous system is associated with daily ratings of positive mood. Psychiatry Res 2004;129:11-9. [PubMed]

34. aan het Rot M, Moskowitz DS, Pinard G, et al. Social behaviour and mood in everyday life: effects of tryptophan in quarrelsome individuals. J Psychiatry Neurosci 2006;31:253-62. [PMC free article] [PubMed]

35. Muldoon MF, Mackey RH, Williams KV, et al. Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity. J Clin Endocrinol Metab 2004; 89:266-71. [PubMed]

36. Perreau-Linck E, Beauregard M, Gravel P, et al. In vivo measurements of brain trapping of α-[11C]methyl-L-tryptophan during acute changes in mood states. J Psychiatry Neurosci 2007;32:430-4. [PMC free article] [PubMed]

37. Kjaer TW, Bertelsen C, Piccini P, et al. Increased dopamine tone during meditation-induced change of consciousness. Brain Res Cogn Brain Res 2002;13:255-9. [PubMed]

38. Golden RN, Gaynes BN, Ekstrom RD, et al. The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence. Am J Psychiatry 2005;162:656-62. [PubMed]

39. Lam RW, Carter D, Misri S, et al. A controlled study of light therapy in women with late luteal phase dysphoric disorder. Psychiatry Res 1999;86:185-92. [PubMed]

40. Epperson CN, Terman M, Terman JS, et al. Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings. J Clin Psychiatry 2004;65:421-5. [PubMed]

41. Carlsson A, Svennerholm L, Winblad B. Seasonal and circadian monoamine variations in human brains examined post mortem. Acta Psychiatr Scand Suppl 1980;280:75-85. [PubMed]

42. Lambert GW, Reid C, Kaye DM, et al. Effects of sunlight and season on serotonin turnover in the brain. Lancet 2002;360:1840-2. [PubMed]

43. Ferraro JS, Steger RW. Diurnal variations in brain serotonin are driven by the photic cycle and are not circadian in nature. Brain Res 1990;512:121-4. [PubMed]

44. Cagampang FRA, Yamazaki S, Otori Y, et al. Serotonin in the raphe nuclei: regulation by light and an endogenous pacemaker. Neuroreport 1993;5:49-52. [PubMed]

45. Mosko SS, Jacobs BL. Midbrain raphe neurons: Spontaneous activity and response to light. Physiol Behav 1974;13:589-93. [PubMed]

46. Abizaid A, Mezei G, Thanarajasingam G, et al. Estrogen enhances light-induced activation of dorsal raphe serotonergic neurons. Eur J Neurosci 2005;21:1536-46. [PubMed]

47. Fite KV, Janusonis S, Foote W, et al. Retinal afferents to the dorsal raphe nucleus in rats and Mongolian gerbils. J Comp Neurol 1999;414:469-84. [PubMed]

48. Fite KV, Wu PS, Bellemer A. Photostimulation alters c-Fos expression in the dorsal raphe nucleus. Brain Res 2005;1031:245-52. [PubMed]

49. aan het Rot M, Benkelfat C, Boivin DB, et al. Bright light exposure during acute tryptophan depletion prevents a lowering of mood in mildly seasonal women. Eur Neuropsychopharmacol. Epub 2007 Jun 18 ahead of print. [PubMed]

50. aan het Rot M, Moskowitz DS, Young SN. Exposure to bright light is associated with positive social interaction and good mood over short time periods: a naturalistic study in mildly seasonal people. J Psychiatr Res DOI:10.1016/j.jpsychires.2006.11.010. Epub 2007 Jan 31 ahead of print. [PubMed]

51. Light cafe to beat the winter blues. BBC News. Available: http://news.bbc.co.uk/2/hi/health/4595626.stm (accessed 2007 Oct 3).

52. Leidig M. Austrian town uses mirrors to tackle lack of daylight. BMJ 2005;331:1162. [PMC free article]

53. Salmon P. Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory. Clin Psychol Rev 2001;21:33-61. [PubMed]

54. National Institute for Health and Clinical Excellence. Depression: management of depression in primary and secondary care - NICE guidance. Available: www.nice.org.uk/page.aspx?o=235213 (accessed 2007 Oct 3).

55. Trivedi MH, Greer TL, Grannemann BD, et al. TREAD: TReatment with Exercise Augmentation for Depression: study rationale and design. Clin Trials 2006;3:291-305. [PubMed]

56. Post RM, Goodwin FK. Simulated behavior states: An approach to specificity in psychobiological research. Biol Psychiatry 1973;7:237-54. [PubMed]

57. Chaouloff F, Elghozi JL, Guezennec Y, et al. Effects of conditioned running on plasma, liver and brain tryptophan and on brain 5-hydroxytryptamine metabolism of the rat. Br J Pharmacol 1985;86:33-41. [PMC free article] [PubMed]

58. Wilson WM, Marsden CA. In vivo measurement of extracellular serotonin in the ventral hippocampus during treadmill running. Behav Pharmacol 1996;7:101-4. [PubMed]

59. Gomez-Merino D, Béquet F, Berthelot M, et al. Site-dependent effects of an acute intensive exercise on extracellular 5-HT and 5-HIAA levels in rat brain. Neurosci Lett 2001;301:143-6. [PubMed]

60. Meeusen R, Piacentini MF, Kempenaers F, et al. Brain neurotransmitter levels during exercise. Dtsch Z Sportmed 2001;52:361-8.

61. Jacobs BL, Fornal CA. Activity of serotonergic neurons in behaving animals. Neuropsychopharmacology 1999;21:9S-15S. [PubMed]

62. Rueter LE, Jacobs BL. A microdialysis examination of serotonin release in the rat forebrain induced by behavioral/environmental manipulations. Brain Res 1996;739:57-69. [PubMed]

63. Chaouloff F, Laude D, Guezennec Y, et al. Motor activity increases tryptophan, 5-hydroxyindoleacetic acid, and homovanillic acid in ventricular cerebrospinal fluid of the conscious rat. J Neurochem 1986;46:1313-6. [PubMed]

64. Davis JM, Alderson NL, Welsh RS. Serotonin and central nervous system fatigue: nutritional considerations. Am J Clin Nutr 2000;72(2 Suppl):573S-8S. [PubMed]

65. Blomstrand E. Amino acids and central fatigue. Amino Acids 2001;20:25-34. [PubMed]

66. Pardridge WM. Blood-brain barrier transport of nutrients. Nutr Rev 1986;44(Suppl):15-25. [PubMed]

67. Young SN. The clinical psychopharmacology of tryptophan. In: Wurtman RJ, Wurtman JJ, editors. Food constituents affecting normal and abnormal behaviors. New York: Raven Press; 1986. p. 49-88.

68. Lambert KG. Rising rates of depression in today's society: Consideration of the roles of effort-based rewards and enhanced resilience in day-to-day functioning. Neurosci Biobehav Rev 2006;30:497-510. [PubMed]

69. Young SN, Gauthier S. Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid, and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid. J Neurol Neurosurg Psychiatry 1981;44:323-7. [PMC free article] [PubMed]

70. Thomson J, Rankin H, Ashcroft GW, et al. The treatment of depression in general practice: a comparison of L-tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo. Psychol Med 1982;12:741-51. [PubMed]

71. Wurtman RJ, Hefti F, Melamed E. Precursor control of neurotransmitter synthesis. Pharmacol Rev 1980;32:315-35. [PubMed]

72. Booij L, Merens W, Markus CR, et al. Diet rich in alpha-lactalbumin improves memory in unmedicated recovered depressed patients and matched controls. J Psychopharmacol 2006;20:526-35. [PubMed]

73. Markus CR, Olivier B, de Haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr 2002;75:1051-6. [PubMed]

74. Kerem Z, Lev-Yadun S, Gopher A, et al. Chickpea domestication in the Neolithic Levant through the nutritional perspective. J Archaeol Sci 2007;34:1289-93.

75. Katz SH, Hediger ML, Valleroy LA. Traditional maize processing techniques in the new world: traditional alkali processing enhances the nutritional quality of the maize. Science 1974;184:765-73. [PubMed]

76. Xue-Cun C, Tai-An Y, Xiu-Zhen T, et al. Opaque-2 maize in the prevention and treatment of pellagra. Nutr Res 1983;3:171-80.

77. Morris CE, Sands DC. The breeder's dilemma — yield or nutrition? Nat Biotechnol 2006;24:1078-80. [PubMed]

78. Mawson AR, Jacobs KW. Corn consumption, tryptophan, and cross-national homicide rates. J Orthomolec Psychiatry 1978;7:227-30.

79. Voracek M, Tran US. Dietary tryptophan intake and suicide rate in industrialized nations. J Affect Disord 2007;98:259-62. [PubMed]