As Covid-19 creeps across the region, fears mount over how it will unfold. Will a young population help stem the spread of disease, or will it unleash catastrophe on creaking health systems?Coronavirus – latest updatesSee all our coronavirus coverageJust seven weeks after Africa recorded its first case of Covid-19 – an Italian national in Algeria – the virus is creeping across the continent, infecting more than 10,000 people and causing 487 deaths. Three of the region’s 54 countries – São Tome and Principe, Comoros, and Lesotho – remain apparently virus-free.“Case numbers are increasing exponentially in the African region,” said Dr Matshidiso Moeti, the World Health Organization (WHO) regional director for Africa. “It took 16 days from the first confirmed case in the region to reach 100 cases. It took a further 10 days to reach the first thousand. Three days after this, there were 2,000 cases, and two days later we were at 3,000.” Continue reading...
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Trump calls out New Zealand’s ‘terrible’ Covid surge; Ibiza bans pool parties, as Spain infections surge;...Trump calls out New Zealand’s ‘terrible’ Covid surge; Ibiza bans pool parties, as Spain infections surge; 70 workers test positive at UK desserts factory. Follow the latestTrump calls out NZ’s Covid surge, on day it records nine new casesAlarm over Covid case rates in 19 European countriesNorth Carolina’s flagship university moves online after 130 casesCovid-19 climbdowns: the UK government’s U-turns and misstepsAustralia coronavirus – live updates 1.07am BST President Trump has singled out New Zealand as country which had coronavirus under control but has subsequently suffered a “big surge”. The places they were using to hold up now they’re having a big surge … they were holding up names of countries and now they’re saying ‘whoops!,” he said at a campign rally in Mankato, Minnesota.Do you see what’s happening in New Zealand? They beat it, they beat it, it was like front-page news because they wanted to show me something. Big surge in New Zealand, you know it’s terrible, we don’t want that, but this is an invisible enemy that should never have been let to come to Europe and the rest of the world by China."All of a sudden a lot of the places they were using to hold up, they are having a big surge ... New Zealand, you see what's going on in New Zealand" -- New Zealand had nine (9!) new Covid cases today. The US had more than 42,000. The outbreaks are not comparable. pic.twitter.com/T8ugmKK6aa Related: Trump calls out New Zealand’s 'terrible' Covid surge, on day it records nine new cases 12.49am BST Lebanon’s health minister warned Monday that hospitals are reaching maximum capacity to treat Covid-19. The country has seen a spike in coronavirus-related cases and deaths in recent weeks and its medical system has been under huge pressure since the massive blast that ripped through Beirut two weeks ago. The World Health Organization on 12 August said more than half of 55 healthcare facilities evaluated by the agency were “non-functional”, three major hospitals were out of operation and another three were running at well below normal capacity. Continue reading...
Continent is seeing more cases spread to the provinces; Trump supporters can’t sue over catching Covid-19...Continent is seeing more cases spread to the provinces; Trump supporters can’t sue over catching Covid-19 at rallies; Brazil confirms 30,000 new casesCoronavirus – latest updatesSee all our coronavirus coverageThe World Health Organization has warned that the coronavirus pandemic is accelerating in Africa, after the continent hit 200,000 cases earlier this week. Speaking at a video briefing hosted by the UN press association in Geneva on Thursday, Doctor Matshidiso Moeti, the WHO’s regional director for Africa, said, “It took 98 days to reach the first 100,000 cases, and only 18 days to move to 200,000 cases.” Africa has so far recorded 5,635 deaths. Continue reading...
Coronavirus researchers are crafting drug cocktails with Gilead's antiviral remdesivir, tapping the HIV playbook to fight the coronavirus
With the antiviral drug remdesivir showing modest benefits for COVID-19 patients, scientists are already plotting how...With the antiviral drug remdesivir showing modest benefits for COVID-19 patients, scientists are already plotting how to rapidly build on this progress. On its own, remdesivir is unlikely to be a game-changer in treating the coronavirus, researchers said. But finding the right drugs to combine it with could produce a much more potent therapy. It is likely to spur a flurry of combination trials that test remdesivir plus additional experimental drugs, leading COVID-19 researchers and physicians said. This mirrors the approach used for HIV, where the first drugs showed modest benefits. It took years of testing combinations to find cocktails of two or three drugs that knocked out the virus. There's optimism this testing will happen more quickly than HIV, with many therapeutic candidates already identified. Biomedical breakthroughs have built an understanding of the virus in record time, as shown by research published Thursday by a group of more than 100 scientists. Visit Business Insider's homepage for more stories. Researchers are already plotting how to build on top of the first effective coronavirus treatment. The key will be crafting the right cocktail of medications, testing additional drugs in combination with the antiviral remdesivir, COVID-19 researchers told Business Insider. This will likely lead to an explosion in combination trials testing Gilead's treatment in addition to experimental drugs to see if any boosts the benefits. HIV and cancer research have both followed a similar path, providing lessons to guide speedy COVID-19 work. Hospitalized COVID-19 patients recovered 31% faster when taking remdesivir instead of a placebo, according to preliminary study results released Wednesday by the US National Institutes of Health. Unlike the majority of early coronavirus studies, this trial's design was high quality, with data from more than 1,000 patients randomized to receive either Gilead's drug or a placebo. That 31% benefit is significant, said Dr. Jeffrey Gold, the chancellor of the University of Nebrasksa's Medical Center, one of the first hospitals to start testing remdesivir. Remdesivir's use should help free up hospital beds, intensive care units, and ventilators as patients recover faster on the drug. But the real advantage will be its potential to serve as a backbone in combination studies, Gold said. "It's a very healthy starting point," Gold said. "It opens the door to multiple combination therapies working in different ways to attack the pandemic, which will hopefully be accelerated." Read more: A failed Ebola drug is now the frontrunner to be the first effective coronavirus treatment. Here's everything you need to know about Gilead's remdesivir. Combination therapies were the true game-changers in fighting HIV The first medications for HIV were single drugs with modest benefits. The real breakthroughs came after years of testing combinations of these drugs, when three-drug cocktails led to dramatic improvements in patients. "We know clearly, as instructed by the global experience in HIV, that combination therapies often have advantages compared to single-drug therapy," Dr. Andrew Badley, director of the Mayo Clinic's HIV Immunology Laboratory, said in an interview. It won't be long before researchers start launching trials testing additional therapies on top of remdesivir, he said. "Those are critical trials, and I think will be coming in the relatively near term," said Badley, who chairs Mayo's COVID-19 research task force. At least one such trial is about to start. Remdesivir will be tested in combination with an arthritis drug The NIH's trial will soon start testing a combination therapy, said Dr. Taison Bell, an assistant professor of medicine and infectious disease at the University of Virginia, where he is a principal investigator for this study. Potentially as soon as next week, patients in the NIH study will all receive remdesivir. They will also be randomized to receive either a placebo or an arthritis drug called Olumiant, Bell said. Olumiant, made by Eli Lilly, works by interfering with the inflammatory response of the immune system. This could help patients suffering from severe cases of COVID-19, which are often marked by their immune systems overreacting. The NIH confirmed they are testing Olumiant, but declined to provide specifics on the design. The agency said details would be shared in a future announcement. Gilead outlined this trial design Thursday on an earnings call, saying the positive trial results for remdesivir will change how COVID-19 drug research is done. "This now changes the landscape of drug development within COVID-19, being one now has to think about comparing to remdesivir and/or adding to remdesivir," said CEO Daniel O'Day. The two drugs work in different ways. Remdesivir is focused on stopping the virus, while Olumiant may help alleviate some of the worst symptoms that patients suffer. Bell said he is most excited about combination trials where each of the drugs can treat distinct phases of the disease. "Looking at an agent that tries to attack the virus replication, and then an agent that targets the immune system response when it goes out of whack, looks like that would be the ideal combination for people with severe disease," Bell said. There's already a deep bench of drugs to test Finding the best HIV combinations took years and hundreds, if not thousands of trials, Badley said. But he is optimistic coronavirus research will progress much faster, given recent breakthroughs in biomedical capabilities. One research project published Thursday in the journal Nature maps a blueprint of how the coronavirus works. An international team of more than 100 researchers identified the dozens of proteins critical to the coronavirus and the hundreds of proteins in humans it needs to grow and replicate. Then, they found existing drugs that could inhibit these human proteins, hoping that could prevent the virus from growing in cells. They identified 10 drugs that showed strong ability to inhibit the virus when tested in monkey cells. It's an eclectic group of compounds, including antihistamines, antipsychotics, and even cancer treatments. Read more: Here's how 13 top drugmakers are sprinting to develop a coronavirus vaccine or treatment that can halt this pandemic Nevan Krogan, a leader of the project and a biologist at the University of California, San Francisco, said he sees the future of COVID-19 research in "adding multiple drugs like a cocktail." "We are excited to be testing our drugs and compounds in combination with each other as well as other antivirals such as remdesivir," Krogan said. These drugs hold particular potential to work with remdesivir, since they have different targets that aren't covered by Gilead's drug, said UCSF chemist Kevan Shokat, another author of the research. "In that way, we hit multiple aspects of the viral life cycle all at once," Shokat said. Mayo's Badley said research like this project has identified dozens of drugs that can be repurposed against the coronavirus. It gives him hope the timeline for breakthroughs will be much quicker than HIV. "The fact that those publications exist is a testament to where we are with biomedical science today," he said. "We were not in a similar place when HIV came along." "I am personally very optimistic that within weeks to months, we will begin to get significant signals of activity of some of these agents as therapies of COVID," he added.Join the conversation about this story » NOW WATCH: 4 potential coronavirus treatments that researchers are working on right now